Research
The focus of the Doyle lab is to investigate the role of the immune system in recovery after stroke.
The Doyle Lab is working to advance our understanding of the immune system's role in recovery after stroke. For many weeks after stroke a chronic inflammatory response persists at the site of the stroke, allowing neurotoxic inflammatory mediators, such as proteases, cytokines, and antibodies, to cause bystander damage to the surrounding brain tissue. This leads to impaired recovery and, in some instances, cognitive decline.
In addition to targeting foam cells, we are also developing tools that can be used to track inflammation in the injured CNS. Our lab is developing novel brain imaging techniques and identifying new plasma biomarkers that can be used to determine how a patient's immune system is responding to a stroke. In the era of personalized medicine, it is vital that we have tools that can be used to tailor immune modifying drugs to individual needs.
Our team is committed to developing innovative approaches to treating stroke, and we are hopeful that our research will lead to new and effective therapies that can improve outcomes for stroke patients.
