Publications

2025

Peterson IL, Scholpa NE, Bachtle KJ, Frye JB, Loppi SH, Thompson AD, Doyle K, Largent-Milnes TM, Schnellmann RG. Formoterol alters chemokine expression and ameliorates pain behaviors after moderate spinal cord injury in female mice. J Pharmacol Exp Ther. 2025 Feb;392(2):100015. doi: 10.1124/jpet.124.002171. Epub 2024 Nov 22. PMID: 40023611; PMCID: PMC12571147.

Arizanovska D, Bush Iii GF, Dallera CA, Folorunso OO, Frye JB, Doyle KP, Jagid JR, Wolosker H, Monaco BA, Graciolli Cordeiro J, Atkins CM, Griswold AJ, Liebl DJ. Cognitive loss after brain trauma results from sex-specific activation of synaptic pruning processes. Brain. 2025 Aug 12:awaf293. doi: 10.1093/brain/awaf293. Epub ahead of print. PMID: 40796363.

Bartlett MJ, Erickson RP, Frye J, Doyle KP, Pires PW, Witte MH. Manual lymph drainage massage of the head and neck improves cognition and reduces pathological biomarkers in the 5x-FAD mouse model of Alzheimers disease. bioRxiv [Preprint]. 2025 Aug 12:2025.08.08.669361. doi: 10.1101/2025.08.08.669361. PMID: 40832216; PMCID: PMC12363786.

Brezzo G, Zera KA, Straus DE, Goertz JE, Loppi SH, Crumpacker RR, Frye JB, Becktel DA, Cuartero MI, García Culebras A, Dames C, Berchtold D, Fowler JH, Meisel A, Anrather J, Moro MA, Allan SM, Doyle KP, Buckwalter MS, McColl BW. Assessing post-stroke cognition in pre-clinical models: Lessons and recommendations from a multi-center study. J Cereb Blood Flow Metab. 2025 Dec 7:271678X251400241. doi: 10.1177/0271678X251400241. Epub ahead of print. PMID: 41355059; PMCID: PMC12685733.

Becktel DA, Frye JB, Le EH, Schnellmann RG, Doyle KP. Plasma Biomarker Profiling of 2-Hydroxypropyl-β-Cyclodextrin (HPβCD) Treatment in an Aged Mouse Model of Ischemic Stroke. Int J Mol Sci. 2025 Nov 7;26(22):10814. doi: 10.3390/ijms262210814. PMID: 41303302; PMCID: PMC12653018.

2024

Becktel DA, Frye JB, Le EH, Whitman SA, Schnellmann RG, Morrison HW, Doyle KP. Discovering novel plasma biomarkers for ischemic stroke: Lipidomic and metabolomic analyses in an aged mouse model. J Lipid Res. 2024 Sep;65(9):100614. doi: 10.1016/j.jlr.2024.100614. Epub 2024 Aug 2. PMID: 39098585; PMCID: PMC11399596.

Murphy DP, Dickson DC, Fatema AN, Carrasco NG, Doyle KP, Trouard TP, Morrison HW. Chronic consequences of ischemic stroke: Profiling brain injury and inflammation in a mouse model with reperfusion. Physiol Rep. 2024 Jun;12(12):e16118. doi: 10.14814/phy2.16118. PMID: 38923318; PMCID: PMC11194179.

Arizanovska D, Dallera CA, Folorunso OO, Bush GF, Frye JB, Doyle KP, Jagid JR, Wolosker H, Monaco BA, Cordeiro JG, Atkins CM, Griswold AJ, Liebl DJ. Cognitive dysfunction following brain trauma results from sex-specific reactivation of the developmental pruning processes. bioRxiv [Preprint]. 2024 Aug 14:2024.08.13.607610. doi: 10.1101/2024.08.13.607610. Update in: Brain. 2025 Aug 12:awaf293. doi: 10.1093/brain/awaf293. PMID: 39211262; PMCID: PMC11360988.

Maiyo BK, Loppi SH, Morrison HW, Doyle KP. Assessment and Quantification of Foam Cells and Lipid Droplet-Accumulating Microglia in Mouse Brain Tissue Using BODIPY Staining. Bio Protoc. 2024 Nov 5;14(21):e5107. doi: 10.21769/BioProtoc.5107. PMID: 39525975; PMCID: PMC11543782.

Bernard K, Mota JA, Wene P, Corenblum MJ, Saez JL, Bartlett MJ, Heien ML, Doyle KP, Polt R, Hay M, Madhavan L, Falk T. The angiotensin (1-7) glycopeptide PNA5 improves cognition in a chronic progressive mouse model of Parkinson's disease through modulation of neuroinflammation. Exp Neurol. 2024 Nov;381:114926. doi: 10.1016/j.expneurol.2024.114926. Epub 2024 Aug 15. PMID: 39153685.

2023

Loppi SH, Tavera-Garcia MA, Scholpa NE, Maiyo BK, Becktel DA, Morrison HW, Schnellmann RG, Doyle KP. Boosting Mitochondrial Biogenesis Diminishes Foam Cell Formation in the Post-Stroke Brain. Int J Mol Sci. 2023 Nov 23;24(23):16632. doi: 10.3390/ijms242316632. PMID: 38068955; PMCID: PMC10706318.

Loppi SH, Tavera-Garcia MA, Scholpa NE, Maiyo BK, Becktel DA, Morrison HW, Schnellmann RG, Doyle KP. Boosting Mitochondrial Biogenesis Diminishes Foam Cell Formation in the Post-Stroke Brain. Int J Mol Sci. 2023 Nov 23;24(23):16632. doi: 10.3390/ijms242316632. PMID: 38068955; PMCID: PMC10706318.

Loppi SH, Tavera-Garcia MA, Becktel DA, Maiyo BK, Johnson KE, Nguyen TV, Schnellmann RG, Doyle KP. Increased fatty acid metabolism and decreased glycolysis are hallmarks of metabolic reprogramming within microglia in degenerating white matter during recovery from experimental stroke. J Cereb Blood Flow Metab. 2023 Jul;43(7):1099-1114. doi: 10.1177/0271678X231157298. Epub 2023 Feb 11. PMID: 36772984; PMCID: PMC10291449.

2022

Dwyer LJ, Stowe AM, Doyle K, Popovich P, Engler-Chiurazzi E, LeGuern C, Buckwalter MS, Poznansky MC, Sîrbulescu RF. The 2022 FASEB virtual Catalyst Conference on B Cells in Injury and Regeneration, March 30, 2022. FASEB J. 2022 Aug;36(8):e22459. doi: 10.1096/fj.202201027. PMID: 35857314; PMCID: PMC9337863. doi: 10.1096/fj.202201027.

Pederson WP, Ellerman LM, Sandoval EC, Boitano S, Frye JB, Doyle KP, Brooks HL, Polverino F, Ledford JG. Development of a Novel Mouse Model of Menopause-associated Asthma. Am J Respir Cell Mol Biol. 2022 Nov;67(5):605-609. doi: 10.1165/rcmb.2022-0181LE. PMID: 36318015; PMCID: PMC9651199.

Becktel DA, Zbesko JC, Frye JB, Chung AG, Hayes M, Calderon K, Grover JW, Li A, Garcia FG, Tavera-Garcia MA, Schnellmann RG, Wu HJ, Nguyen TV, Doyle KP. Repeated Administration of 2-Hydroxypropyl-β-Cyclodextrin (HPβCD) Attenuates the Chronic Inflammatory Response to Experimental Stroke. J Neurosci. 2022 Jan 12;42(2):325-348. doi: 10.1523/JNEUROSCI.0933-21.2021. Epub 2021 Nov 24. PMID: 34819339; PMCID: PMC8802936.

2021

Zbesko, J.C., J.B. Frye, D.A. Becktel, D.K. Gerardo, J. Stokes, K. Calderon, T.V. Nguyen, D. Bhattacharya, and K.P. Doyle, "IgA natural antibodies are produced following T-cell independent B-cell activation following stroke", Brain Behavior and Immunity, vol. 91, 2021. PMID: 32956832.

Hoyer-Kimura, C., J.P. Konhilas, H.M. Mansour, R. Polt, K.P. Doyle, D. Billheimer, and M. Hay, "Neurofilament light: a possible prognostic biomarker for treatment of vascular contributions to cognitive impairment and dementia.", Journal of Neuroinflammation, vol. 18(1), 10/2021. PMID: 34654436.

Nguyen, T. V., R. H. Crumpacker, K. E. Calderon, F. G. Garcia, J. C. Zbesko, J. B. Frye, S. Gonzalez, D. A. Becktel, T. Yang, M. A. Tavera-Garcia, et al., "Post-stroke administration of the p75 neurotrophin receptor modulator, LM11A-31, attenuates chronic changes in brain metabolism, increases neurotransmitter levels, and improves recovery", Journal of Pharmacology and experimental Therapeutics, vol. JPET-AR-2021-000711, 2021. PMID: 34893553.

2020

Bartlett, M. J., A. J. Flores, T. Ye, S. I. Smidt, H. K. Dollish, J. A. Stancati, D. C. Farrell, K. L. Parent, K. P. Doyle, D. G. Besselsen, et al., "Preclinical evidence in support of repurposing sub-anesthetic ketamine as a treatment for L-DOPA-induced dyskinesia.", Exp Neurol, vol. 333, pp. 113413, 2020 Nov. PMCID: PMC7518549  PMID: 32717354

2019

Hay, M., R. Polt, M. L. Heien, T. W. Vanderah, T. M. Largent-Milnes, K. Rodgers, T. Falk, M. J. Bartlett, K. P. Doyle, and J. P. Konhilas, "A Novel Angiotensin-(1-7) Glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation-Related Memory Dysfunction.", J Pharmacol Exp Ther, vol. 369, issue 1, pp. 9-25, 2019 Apr. PMCID: PMC6413771  PMID: 30709867

Doyle, K. P., and M. S. Buckwalter, "Immunological mechanisms in poststroke dementia.", Curr Opin Neurol, 2019 Nov 27. PMID: 31789707

2018

Zbesko, J. C., T-V. V. Nguyen, T. Yang, J. Beischel Frye, O. Hussain, M. Hayes, A. Chung, A. W Day, K. Stepanovic, M. Krumberger, et al., "Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts.", Neurobiol Dis, vol. 112, pp. 63-78, 2018 Jan 10. PMID: 29331263

Chung, A. G., J. B. Frye, J. C. Zbesko, E. Constantopoulos, M. Hayes, A. G. Figueroa, D. A. Becktel, A. W Day, J. P. Konhilas, B. S. McKay, et al., "Liquefaction of the Brain following Stroke Shares a Similar Molecular and Morphological Profile with Atherosclerosis and Mediates Secondary Neurodegeneration in an Osteopontin-Dependent Mechanism.", eNeuro, vol. 5, issue 5, 2018 Sep-Oct. PMCID: PMC6223114  PMID: 30417081

Nguyen, T-V. V., M. Hayes, J. C. Zbesko, J. B. Frye, N. R. Congrove, N. P. Belichenko, B. S. McKay, F. M. Longo, and K. P. Doyle, "Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia.", Acta Neuropathol Commun, vol. 6, issue 1, pp. 100, 2018 09 24. PMCID: PMC6154927  PMID: 30249297

Taylor, S., E. Mehina, E. White, P. Reeson, K. Yongblah, K. P. Doyle, and C. E. Brown, "Suppressing Interferon-γ Stimulates Microglial Responses and Repair of Microbleeds in the Diabetic Brain.", J Neurosci, vol. 38, issue 40, pp. 8707-8722, 2018 Oct 03. PMID: 30201775

2017

Danilo, C. A., E. Constantopoulos, L. A. McKee, H. Chen, J. A. Regan, Y. Lipovka, S. Lahtinen, L. K. Stenman, T-V. V. Nguyen, K. P. Doyle, et al., "Bifidobacterium animalis subsp. lactis 420 mitigates the pathological impact of myocardial infarction in the mouse.", Benef Microbes, vol. 8, issue 2, pp. 257-269, 2017 Apr 26. PMID: 28409534

2016

Nguyen, T-V. V., J. B. Frye, J. C. Zbesko, K. Stepanovic, M. Hayes, A. Urzua, G. Serrano, T. G. Beach, and K. P. Doyle, "Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissue.", Acta Neuropathol Commun, vol. 4, issue 1, pp. 100, 2016 Sep 06. PMCID: PMC5011964  PMID: 27600707

Doyle, K. P., and M. S. Buckwalter, "Does B lymphocyte-mediated autoimmunity contribute to post-stroke dementia?", Brain Behav Immun, 2016 Aug 13. PMCID: PMC5305803  PMID: 27531189

2015

Doyle, K. P., L. N. Quach, M. Solé, R. C. Axtell, T-V. V. Nguyen, G. J. Soler-Llavina, S. Jurado, J. Han, L. Steinman, F. M. Longo, et al., "B-Lymphocyte-mediated delayed cognitive impairment following stroke.", J Neurosci, vol. 35, issue 5, pp. 2133-45, 2015 Feb 4. PMCID: PMC4315838  PMID: 25653369

Doyle, K. P., L. N. Quach, H. E. D'Arceuil, and M. S. Buckwalter, "Ferumoxytol administration does not alter infarct volume or the inflammatory response to stroke in mice.", Neurosci Lett, vol. 584, pp. 236-40, 2015 Jan 1. PMCID: PMC4268374  PMID: 25449870

2014

Cekanaviciute, E., N. Fathali, K. P. Doyle, A. M. Williams, J. Han, and M. S. Buckwalter, "Astrocytic transforming growth factor-Beta signaling reduces subacute neuroinflammation after stroke in mice.", Glia, vol. 62, issue 8, pp. 1227-40, 2014 Aug. PMCID: PMC4061255  PMID: 24733756

2012

Pollak, J., K. P. Doyle, L. Mamer, M. Shamloo, and M. S. Buckwalter, "Stratification substantially reduces behavioral variability in the hypoxic-ischemic stroke model.", Brain Behav, vol. 2, issue 5, pp. 698-706, 2012 Sep. PMCID: PMC3489820  PMID: 23139913

Doyle, K. P., and M. S. Buckwalter, "The double-edged sword of inflammation after stroke: what sharpens each edge?", Ann Neurol, vol. 71, issue 6, pp. 729-31, 2012 Jun. PMID: 22718541

Han, J., J. Pollak, T. Yang, M. R. Siddiqui, K. P. Doyle, K. Taravosh-Lahn, E. Cekanaviciute, A. Han, J. Z. Goodman, B. Jones, et al., "Delayed Administration of a Small Molecule Tropomyosin-Related Kinase B Ligand Promotes Recovery After Hypoxic-Ischemic Stroke.", Stroke, vol. 43, issue 7, pp. 1918-24, 2012 Jul. PMCID: PMC3383889  PMID: 22535263

Doyle, K. P., N. Fathali, M. R. Siddiqui, and M. S. Buckwalter, "Distal hypoxic stroke: A new mouse model of stroke with high throughput, low variability and a quantifiable functional deficit.", J Neurosci Methods, vol. 207, issue 1, pp. 31-40, 2012 May 30. PMCID: PMC3348433  PMID: 22465679

Csiszar, A., A. Podlutsky, N. Podlutskaya, W. E. Sonntag, S. Z. Merlin, E. E. R. Philipp, K. Doyle, A. Davila, F. A. Recchia, P. Ballabh, et al., "Testing the Oxidative Stress Hypothesis of Aging in Primate Fibroblasts: Is There a Correlation Between Species Longevity and Cellular ROS Production?", J Gerontol A Biol Sci Med Sci, vol. 67, issue 8, pp. 841-52, 2012 Aug. PMCID: PMC3403864  PMID: 22219516

2011

Bahjat, F. Rena, R. L. Williams-Karnesky, S. G. Kohama, A. G West, K. P. Doyle, N. S. Lessov, M. D. Spector, T. R. Hobbs, and M. P. Stenzel-Poore, "Proof of Concept: Pharmacological preconditioning with a Toll-like receptor agonist protects against cerebrovascular injury in a primate model of stroke.", J Cereb Blood Flow Metab, vol. 31, issue 5, pp. 1229-42, 2011 May. PMCID: PMC3099644  PMID: 21285967

2010

Doyle, K. P., E. Cekanaviciute, L. E. Mamer, and M. S. Buckwalter, "TGFβ signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke.", J Neuroinflammation, vol. 7, pp. 62, 2010. PMCID: PMC2958905  PMID: 20937129

2009

G West, A., K. J. Golshani, K. P. Doyle, N. S. Lessov, T. R. Hobbs, S. G. Kohama, M. M. Pike, C. D. Kroenke, M. R. Grafe, M. D. Spector, et al., "A new model of cortical stroke in the rhesus macaque.", J Cereb Blood Flow Metab, vol. 29, issue 6, pp. 1175-86, 2009 Jun. PMCID: PMC2828874  PMID: 19384334

2008

Doyle, K. P., M. P. Stenzel-Poore, and R. P. Simon, "Mechanisms of ischemic brain damage.", Neuropharmacology, vol. 55, issue 3, pp. 310-8, 2008 Sep. PMCID: PMC2603601  PMID: 18308346

Doyle, K. P., S. L. Stevens, N. S. Lessov, T. Yang, T. M. Ciesielski, R. P. Simon, J. S. King, and M. P. Stenzel-Poore, "Nasal administration of osteopontin peptide mimetics confers robust neuroprotection in stroke.", J Cereb Blood Flow Metab, vol. 28, issue 6, pp. 1235-48, 2008 Jun. PMID: 18364727

2005

Meller, R., S. L. Stevens, M. Minami, J. A. Cameron, S. King, H. Rosenzweig, K. Doyle, N. S. Lessov, R. P. Simon, and M. P. Stenzel-Poore, "Neuroprotection by Osteopontin in Stroke.", J Cereb Blood Flow Metab, vol. 25, issue 2, pp. 217-25, 2005 Feb. PMID: 15678124

2003

Doyle, K. P., R. P. Simon, A. Snyder, and M. P. Stenzel-Poore, "Working with GFP in the Brain.", Biotechniques, vol. 34, issue 3, pp. 492-4, 2003 Mar. PMID: 12669698